Evaluation of High-Dose Systemic Methotrexate in Patients with Breast Cancer and Leptomeningeal Metastasis

What we are studying

The doctors have found that you have breast cancer that has traveled to a part of the brain or spine called the leptomeninges (cancer cells that have spread to the membranes that cover your brain and spinal cord). This is usually treated with chemotherapy that is given into the fluid that surrounds the nerves and brain and/or with radiation. In some instances, a medication called methotrexate can be used. Methotrexate is a type of chemotherapy drug (that is given in the vein). High doses of methotrexate, called high-dose methotrexate, have been used in patients with this type of cancer.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
    • Asian
    • American Indian or Alaska Native
    • Native Hawaiian or Pacific Islander
    • Other
  • All Ethnicities
  • Ages 18+

Eligibility Criteria

  • Breast cancer
  • Brain cancer
  • Spinal cord cancer (leptomeninges)

What is involved

  • This clinical research study consists of several parts induction
  • Consolidation and maintenance.


Study related parking will be validated

Contact Information

Study Coordinator
Stacey Lewis
Principal Investigator
Roy C Strowd

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.