MILES (Microbiome Insulin Longitudinal Evaluation Study)

What we are studying

Researchers at Wake Forest Baptist Health are trying to better understand risk factors for type 2 diabetes. There are thought to be links between the foods one eats, the gut and microorganisms that live there, levels of the hormone insulin, and glucose, the main sugar that provides energy for the body to function. This study will be measuring these factors at three different times over three years, to better understand why some people develop type 2 diabetes.

Who is Eligible

  • Genders:
    • Men
    • Women
  • Races:
    • White
    • African American
  • Not Hispanic or Latino
  • Ages 40 - 85

Eligibility Criteria

  • Not currently diagnosed with diabetes
  • Not using a proton pump inhibitor in the past 4 weeks
  • Not using any prescription antacid medications in the past 4 weeks
  • Not using antibiotics in the past 4 weeks

What is involved

  • 3 clinic visits within 3 years (baseline; 15 months; and 30 months) at the CRU
  • Obtaining a stool sample at home prior to each visit to the CRU
  • Answering questionnaires about diet/personal characteristics and health
  • Having a two hour oral glucose tolerance test which involves drinking a sweet beverage and having blood drawn
  • Having height/weight/ blood pressure measured at each visit


Compensation is available for study participants.

Contact Information

Study Coordinator
Mary Kelsey Trumps
Principal Investigator
Dr. Alain Bertoni

Disclaimer: The information on this website is for general informational purposes only and SHOULD NOT be relied upon as a substitute for sound professional medical advice, evaluation or care from your physician or other qualified health care provider.